ABSTRACT
SARS-CoV-2 was a devastating global pandemic that swept the globe in late 2019, claiming the lives of an estimated 4 million people. Amidst challenging times, we are remembering Martin Luther King Jr.'s remark, "Mankind must put an end to war or war will put an end to mankind." In that sense, scientists are repurposing drugs meticulously to curb the nCOVID-19. New antiviral drugs on the other hand are being developed at unparallel rates. Among those Pfizer's inventive Nirmatrelvir/Ritonavir (PaxlovidTM), which inhibits the main protease (Mpro) of SARS-CoV-2, 3CL protease, will be another arrow in the quiver to mount resistance towards SARS-CoV-2. In patients treated with nirmatrelvir/ritonavir within five days of symptom onset, COVID-19-related hospitalizations and mortality were dramatically reduced. Paxlovid's high oral availability, allows it to be used in both hospitalized and outpatient patients. In this brief review, we presented pharmacokinetic, preclinical, and clinical evidence on Paxlovids for the treatment of moderate nCOVID-19.
ABSTRACT
Recent pandemic situation of covid-19 which is caused due to the outbreak of highly dangerous and easily spreadable corona virus is an increasing concern throughout the entire world. The purpose of this study is to develop an alert system which alerts employees to maintain social distance in corporate working environments. A real-Time location systems (RTLS) based on ultra wide band (UWB) wireless technology gives most accurate locations of approximately 10cm using methods like trilateration and TDOA (Time Difference of Arrival). Co-ordinates of the location can be obtained by installing RTLS in predefined area which are used to calculate the distance between Mobile UWB Devices (MUD's). An alert triggered by a system to maintain distance if distance between the employees is less than the prescribed social distance can keep the work premises safe and control the spread of corona virus. This study can be a great solution to control spread of virus in corporate working environments which are mostly of confined in size and indoor in nature. © 2020 IEEE.